For Contract Research Organizations
Built for CRO feasibility operations — not patient recruitment campaigns
Cohortbridge is a patient matching platform designed for CRO clinical operations teams running Phase II/III feasibility assessments. It replaces manual chart review with structured EHR-to-protocol eligibility matching.
What CRO ops teams tell us keeps them up at night
1–2 CRA Days per Site
Feasibility assessments consume a large fraction of CRA time — most of it reviewing charts for patients who ultimately don't qualify. That time can't be recovered.
Site Selection Built on Guesswork
Historical enrollment data from prior trials tells you where patients enrolled before — not how many eligible patients exist now, for this protocol, at this site. The error propagates into enrollment timelines.
Sponsor Pressure Without the Data
Sponsors want enrollment timeline commitments early in the feasibility process — before CRAs have had time to complete manual chart review. CROs end up giving estimates before they have real numbers.
From protocol receipt to enrollment estimate in days
Upload the protocol and define inclusion/exclusion criteria
Upload the clinical protocol or provide the I/E criteria directly. The Cohortbridge clinical informatics team validates the criteria parsing before the first match run. This one-time setup takes 2–3 business days for standard indications.
Cohortbridge runs matching against connected EHR sites
For sites already connected to the Cohortbridge network, matching runs within hours of protocol setup. For new sites, EHR access agreement execution adds 4–6 weeks to the timeline — but that investment covers future protocols at the same site.
Review ranked cohort estimates per site
The CRO feasibility team receives a per-site breakdown: estimated eligible patient count, confidence score distribution, criteria match rate. This is the enrollment estimate — not a historical approximation, but a prospective count based on current patient records.
Redirect CRA time from discovery to confirmation
Chart review shifts from "find patients who might qualify" to "confirm the eligibility of patients who the matching engine identified as likely candidates." CRA time is spent more efficiently. Sponsor reporting is backed by structured data, not individual reviewer notes.
The difference between estimated and matched enrollment
CROs that commit to enrollment estimates based on historical data regularly find that actual eligible patient populations at sites differ from estimates — sometimes dramatically, especially for narrow indication areas or protocols with multiple complex exclusion criteria.
Cohortbridge-based estimates reflect current, protocol-specific patient populations — before any site activation or chart review resource allocation.
See enrollment impact dataWithout Cohortbridge
With Cohortbridge
Directional ranges from internal pilot programs. Individual results vary by protocol complexity and EHR data completeness.
"Cohortbridge changed how we estimate enrollment for feasibility submissions. Instead of running our calculations from historical data and hoping the site still looks the same two years later, we're working from current EHR populations. The confidence difference is significant."
"The IRB documentation and data flow description that Cohortbridge provides was exactly what our sponsor needed before signing off on the EHR access agreement. We've had those conversations take 3 months in the past. Having pre-prepared architecture documentation shortened that review significantly."
Implementation in four steps
For CROs with sites already connected to the Cohortbridge network, first match run can begin within days of protocol setup. For new sites, EHR access agreement execution is the primary timeline driver.
EHR Access Agreement
Execute data use agreement with participating health system. Cohortbridge provides standard DUA templates reviewed by clinical informatics counsel.
Protocol Upload
Upload protocol I/E criteria. Clinical informatics team validates structured criteria parsing — 2–3 business days for standard indications.
Pilot Match Run
Run matching against a single connected site to validate criteria accuracy and cohort output format before full deployment.
Full Deployment
Scale matching across all enrolled sites. Receive per-site cohort estimates for sponsor feasibility submission.
Start with a pilot on your next protocol
We work with CRO feasibility teams on a protocol-by-protocol basis. Contact us to discuss a pilot match run for your current or upcoming Phase II/III study.